Description

Xorphanol is a potent synthetic opioid analgesic compound with significant research and development interest. Its primary value lies in its high-affinity binding to opioid receptors, making it a critical reference standard and intermediate in pharmaceutical research for studying pain management pathways. This compound is essential for research laboratories, pharmaceutical developers, and analytical facilities focused on neuropharmacology, analgesic drug discovery, and forensic chemistry. Xorphanol CAS NO 77287-90-2 is handled under strict regulatory controls due to its pharmacological activity.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control in drug testing and forensic analysis.
• Biomedical Research: Serves as a key pharmacological tool in in vitro and in vivo studies to investigate opioid receptor function, signal transduction, and the mechanisms of analgesia and addiction.
• Drug Discovery & Development: Acts as a crucial intermediate or lead compound in the synthesis and structure-activity relationship (SAR) studies of novel analgesic agents.
• Metabolic Studies: Utilized in research to identify and quantify metabolites for pharmacokinetic and toxicological profiling.
• Forensic Science: Employed as a calibrant and control substance in the detection and confirmation of synthetic opioids in forensic toxicology laboratories.

Basic Information

Product Name	Xorphanol
CAS No.	77287-90-2
Molecular Formula	C24H31NO4
Molecular Weight	397.51 g/mol
Synonyms	Xorphanol; (-)-Xorphanol; (5R,9R,13S,14S)-4,5-Epoxy-3,14-dihydroxy-17-(2-methylbutyl)morphinan-6-one; 3,14-Dihydroxy-4,5-epoxy-17-(2-methylbutyl)morphinan-6-one; U-62066; U 62066; U62066; Spiradoline mesylate related compound C (base).
EINECS	Contact for details

Quality Control

We supply Xorphanol in high-purity grades suitable for research and development. Every batch is manufactured and handled under strict quality management systems. Identity and purity are confirmed through a battery of analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under recommended conditions at controlled room temperature (15-25°C) or as specified on the label or COA. The product should be kept in a secure, controlled-access environment in compliance with all applicable regulations for controlled substances.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.