Description

1-o-Octadecyl-2-o-Methyl-Sn-Glycero-3-Phosphocholine is a high-purity synthetic phospholipid, specifically an ether-linked phosphatidylcholine analogue. This compound is a critical building block in advanced lipid research and formulation, valued for its unique structural stability and membrane-mimicking properties. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation drug delivery systems, such as liposomes and lipid nanoparticles (LNPs), as well as for fundamental studies in membrane biophysics.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural lipid component for the encapsulation and delivery of nucleic acid therapeutics (mRNA, siRNA).
• Liposome Production: Used to create stable, long-circulating liposomal vesicles for targeted drug delivery and diagnostic applications.
• Membrane Biophysics Research: Serves as a model membrane lipid to study lipid raft formation, membrane fluidity, and protein-lipid interactions due to its ether-linked alkyl chains.
• Cell Culture & Transfection Reagents: Incorporated into lipid mixtures to enhance the efficiency of in vitro transfection protocols.
• Biomimetic Coatings & Sensors: Utilized in the development of biosensors and biocompatible surface coatings that mimic natural cell membranes.
• Reference Standard: Acts as a high-purity analytical standard for quality control in pharmaceutical lipid manufacturing and research.

Basic Information

Product Name	1-o-Octadecyl-2-o-Methyl-Sn-Glycero-3-Phosphocholine
CAS No.	77286-66-9
Molecular Formula	C₂₇H₅₈NO₆P
Molecular Weight	523.73 g/mol
Synonyms	1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; 1-Stearyl-2-methyl-rac-glycero-3-phosphocholine; Ether PC(18:0/2:0); 1-Octadecyl-2-methyl-sn-glycero-3-phosphocholine; Methyl-DSA; 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine; rac-1-O-Octadecyl-2-O-methylglycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our 1-o-Octadecyl-2-o-Methyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.