Description

(1S)-6,7-Dimethoxy-1-Methyl-2-(2-Methyl-1-Oxopropyl)-1,2,3,4-Tetrahydroisoquinoline is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of complex pharmaceutical molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities, particularly within the fields of neurology and cardiovascular research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the development of compounds targeting neurological pathways and receptors.
• Asymmetric Synthesis: Serves as a precursor for constructing molecules with specific stereochemistry in medicinal chemistry programs.
• Cardiovascular Drug Development: Employed in research for creating novel therapeutic agents for cardiovascular diseases.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Process Chemistry & Scale-up: Supports route scouting and optimization for the commercial-scale manufacturing of specialty chemicals.

Basic Information

Product Name	(1S)-6,7-Dimethoxy-1-Methyl-2-(2-Methyl-1-Oxopropyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	77280-41-2
Molecular Formula	C₁₆H₂₃NO₃
Molecular Weight	277.36 g/mol
Synonyms	(S)-6,7-Dimethoxy-1-methyl-2-(2-methylpropanoyl)-1,2,3,4-tetrahydroisoquinoline; (1S)-6,7-Dimethoxy-1-methyl-2-(2-methyl-1-oxopropyl)-1,2,3,4-tetrahydroisoquinoline; (S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methyl-2-(2-methyl-1-oxopropyl)isoquinoline; (S)-6,7-Dimethoxy-1-methyl-2-isobutyryl-1,2,3,4-tetrahydroisoquinoline; (S)-Tetrahydropapaverine isobutyryl derivative; (S)-THP-Isobutyryl; Chiral Tetrahydroisoquinoline Derivative; 77280-41-2
EINECS	Contact for details

Quality Control

Our (1S)-6,7-Dimethoxy-1-Methyl-2-(2-Methyl-1-Oxopropyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.