Description

4-Pentyne-1-Thiol is a specialized alkyne-terminated thiol compound, serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both a terminal alkyne and a thiol group, makes it an invaluable reagent for click chemistry, polymer modification, and surface functionalization. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, materials science, and specialty chemical industries developing novel polymers, ligands, and bio-conjugates.

Application

• Click Chemistry Reagent: A key component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer synthesis.
• Polymer & Surface Modification: Used to introduce thiol or alkyne functional groups onto polymer chains, nanoparticles, or gold surfaces for tailored material properties.
• Pharmaceutical Intermediate: Serves as a versatile synthon in the research and development of new active pharmaceutical ingredients (APIs) and prodrugs.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Crosslinking Agent: Functions as a difunctional crosslinker in the formulation of thiol-ene networks and specialty adhesives.
• Chemical Biology Probes: Utilized for labeling and studying biological molecules via thiol-maleimide or alkyne-azide coupling strategies.

Basic Information

Product Name	4-Pentyne-1-Thiol
CAS No.	77213-88-8
Molecular Formula	C5H8S
Molecular Weight	100.18 g/mol
Synonyms	1-Pentyn-4-thiol; 4-Pentyn-1-thiol; 4-Pentyne-1-thiol; Pent-4-yne-1-thiol; 1-Mercapto-4-pentyne; 4-Pentynyl mercaptan; 1-Thiol-4-pentyne
EINECS	Contact for details

Quality Control

Our 4-Pentyne-1-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep away from heat, sparks, and open flames. For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles and exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.