Description

R(-)-γ-Vinyl Gaba CAS NO 77162-51-7 is the (R)-enantiomer of γ-vinyl-GABA, a chiral building block and key intermediate of significant interest in pharmaceutical research and development. This high-purity stereoisomer is crucial for the synthesis of active pharmaceutical ingredients (APIs) targeting neurological pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly for central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of advanced GABAergic compounds and other neuroactive agents.
• Neurological Research: Used as a reference standard and building block in preclinical studies investigating GABA (γ-aminobutyric acid) neurotransmission and related mechanisms.
• API Development: Serves as a key starting material or intermediate in the multi-step synthesis of potential drug candidates for epilepsy, neuropathic pain, and other CNS conditions.
• Asymmetric Synthesis: Employed in stereoselective synthesis processes where the specific (R)-configuration is required for biological activity.
• Biochemical Studies: Utilized in enzymatic and receptor-binding assays to study selectivity and interaction with biological targets.
• Process Chemistry: Serves as a high-value intermediate in the scale-up and optimization of manufacturing routes for pharmaceutical actives.

Basic Information

Product Name	R(-)-γ-Vinyl Gaba
CAS No.	77162-51-7
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(R)-γ-Vinyl-GABA; (R)-Vigabatrin; (3R)-4-Amino-5-hexenoic Acid; (R)-4-Aminohex-5-enoic Acid; (R)-GAV; (R)-γ-Vinyl GABA; (R)-GVG; (R)-Sabril (intermediate)
EINECS	Contact for details

Quality Control

Our R(-)-γ-Vinyl Gaba is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.