Description

L-7-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, synthetically valuable heterocyclic building block. This compound is essential for pharmaceutical research and development, serving as a key chiral intermediate in the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential central nervous system (CNS) active compounds, enzyme inhibitors, and receptor ligands.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new therapeutic agents.
• Peptidomimetics & Constrained Analogs: Serves as a rigid, bicyclic scaffold to mimic peptide secondary structures and improve metabolic stability.
• Agrochemical Synthesis: Employed in the development of novel herbicides or plant growth regulators with specific chiral requirements.
• Asymmetric Catalysis Ligand Precursor: Can be functionalized to create novel chiral ligands for asymmetric synthesis.
• Chemical Biology Probes: Used to develop molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Detail
Product Name	L-7-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	77141-10-7
Molecular Formula	C10H10BrNO2
Molecular Weight	256.10 g/mol
Synonyms	(3S)-7-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; L-7-Bromo-Tic-OH; 7-Bromo-L-Tic; (S)-7-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 7-Bromo-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 7-Bromo-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 7-Bromo-Tic; BRTIC
EINECS	Contact for details

Quality Control

Our L-7-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.