Description

2-(2-Chloro-Acetylamino)-5,6,7,8-Tetrahydro-4H-Cyclohepta[B]Thiophene-3-Carboxylic Acid Ethyl Ester is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmacologically active molecules, particularly within the thiophene and fused-ring chemical classes. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of new chemical entities (NCEs) for drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory pathways, or metabolic diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery projects.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Synthesis: Potential intermediate for developing novel herbicides, fungicides, or insecticides due to its fused thiophene structure.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and advanced organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the life sciences industry.

Basic Information

Product Name	2-(2-Chloro-Acetylamino)-5,6,7,8-Tetrahydro-4H-Cyclohepta[B]Thiophene-3-Carboxylic Acid Ethyl Ester
CAS No.	76981-88-9
Molecular Formula	C14H18ClNO3S
Molecular Weight	315.81 g/mol
Synonyms	Ethyl 2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 2-(2-Chloroacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester; 2-(2-Chloroacetylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic Acid Ethyl Ester; 4,5,6,7-Tetrahydro-2-[(2-chloroacetyl)amino]benzo[b]thiophene-3-carboxylic acid ethyl ester; Ethyl 2-(2-chloroacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate; 76981-88-9; 2-(2-Chloroacetylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of 2-(2-Chloro-Acetylamino)-5,6,7,8-Tetrahydro-4H-Cyclohepta[B]Thiophene-3-Carboxylic Acid Ethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.