Description

3-Iodopindolol is a high-purity iodinated derivative of the non-selective β-adrenergic receptor antagonist pindolol. This compound serves as a crucial pharmaceutical intermediate and research chemical, primarily valued for its utility in the development and study of novel β-blockers and radioligands. It is essential for pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in cardiovascular drug discovery and molecular pharmacology.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel iodinated β-adrenergic receptor blockers and other active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a precursor or reference standard in studies investigating β-adrenergic receptor binding, function, and signaling pathways.
• Radioligand Development: Serves as a starting material for the synthesis of radioiodinated tracers (e.g., [¹²³I] or [¹³¹I] labeled compounds) for SPECT imaging and research.
• Metabolite & Impurity Standard: Employed as an analytical reference standard in HPLC or LC-MS methods for quality control and pharmacokinetic studies of pindolol-related drugs.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to develop new cardiovascular agents with modified potency or selectivity.

Basic Information

Product Name	3-Iodopindolol
CAS No.	76875-01-9
Molecular Formula	C₁₄H₂₀IN₃O₂
Molecular Weight	389.23 g/mol
Synonyms	1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-iodopropan-2-ol; 3-Iodo-Pindolol; 4-[3-(Iodohydroxy)-2-(isopropylamino)propoxy]indole; Pindolol, 3-iodo-; Iodopindolol; 3-Iodo-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
EINECS	Contact for details

Quality Control

Our 3-Iodopindolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.