Description

6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is a high-purity, versatile heterocyclic building block of significant interest in advanced organic synthesis. Its unique fused-ring structure containing both carboxylic acid and phenolic hydroxyl functional groups makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Organic Synthesis Building Block: Utilized in the construction of complex isoquinoline and tetrahydroisoquinoline derivatives for medicinal chemistry and material science applications.
• Ligand and Catalyst Precursor: Its bifunctional nature allows for use in synthesizing specialized ligands for asymmetric catalysis and metal complexation.
• Biochemical Research: Employed in the study of enzyme inhibitors and as a scaffold for probing biological pathways.
• Fine Chemical Production: Used in the multi-step synthesis of high-value specialty chemicals, dyes, and advanced materials.

Basic Information

Product Name	6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid
CAS No.	76824-99-2
Molecular Formula	C10H11NO3
Molecular Weight	193.20 g/mol
Synonyms	6-Hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; 3-Carboxy-6-hydroxy-1,2,3,4-tetrahydroisoquinoline; 6-Hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (3S)-6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (for S-enantiomer); (3R)-6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (for R-enantiomer); 6-OH-Tic-OH; THIQ-3-COOH-6-OH
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, and our quality protocols are designed to support cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled with appropriate precautions for strong acid/organic solvent compatibility. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.