Description

6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is a key heterocyclic building block and chiral synthon of significant interest in advanced organic synthesis. This compound is valued for its rigid, fused-ring structure and functional groups, which make it a versatile precursor for complex molecular architectures. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular research areas.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex alkaloids and novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Organic Synthesis Reagent: Used as a versatile synthon in asymmetric synthesis, cyclization reactions, and the construction of complex polycyclic frameworks in academic and industrial research.
• Agrochemical Research: Serves as a precursor in the development of new crop protection agents and herbicides, leveraging its unique heterocyclic core.
• Biochemical Research: Employed in the study of enzyme inhibitors and receptor ligands due to its structural similarity to natural isoquinoline alkaloids.
• Material Science: Investigated as a monomer or functional additive for specialty polymers and advanced organic materials.

Basic Information

Product Name	6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid
CAS No.	76824-86-7
Molecular Formula	C₁₂H₁₅NO₄
Molecular Weight	237.25 g/mol
Synonyms	6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; 3-Carboxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 3-Carboxy-6,7-dimethoxytetrahydroisoquinoline; THIQ-3-COOH derivative; DTIC; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.