Description

1,1-Bis(4-Fluorophenyl)-2-(1,2,4-Triazol-1-Yl)Ethanol is a high-purity, non-steroidal aromatase inhibitor intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of potent and selective aromatase inhibitors used in therapeutic applications. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers targeting hormone-dependent conditions. The material's specific structure is essential for developing advanced treatment formulations.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the production of non-steroidal aromatase inhibitor drugs.
• Oncology Research: Used in the development and manufacture of therapeutics for hormone-responsive cancers, such as breast cancer.
• Endocrinology Drug Development: Serves as a core structure in creating compounds that regulate estrogen synthesis.
• API Synthesis: Employed in multi-step synthetic routes for final Active Pharmaceutical Ingredient (API) production under GMP conditions.
• Biochemical Research: Utilized as a reference standard and tool compound in enzymatic studies related to the aromatase enzyme complex.
• Process Chemistry & Scale-Up: Integral for process optimization and pilot-scale manufacturing of advanced drug candidates.

Basic Information

Product Name	1,1-Bis(4-Fluorophenyl)-2-(1,2,4-Triazol-1-Yl)Ethanol
CAS No.	76674-14-1
Molecular Formula	C16H13F2N3O
Molecular Weight	301.29 g/mol
Synonyms	1,1-Bis(4-Fluorophenyl)-2-(1H-1,2,4-Triazol-1-yl)ethanol; 1,1-Bis(p-Fluorophenyl)-2-(1,2,4-triazol-1-yl)ethanol; 2-(1,2,4-Triazol-1-yl)-1,1-bis(4-fluorophenyl)ethanol; Letrozole Intermediate; CGS 20267 Intermediate; Femara Intermediate; 4,4'-(1H-1,2,4-Triazol-1-yl)methylene]bis(fluorobenzene); (RS)-1,1-Bis(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)ethanol
EINECS	Contact for details

Quality Control

Our 1,1-Bis(4-Fluorophenyl)-2-(1,2,4-Triazol-1-Yl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.