Description

T-Butyldiphenylmethoxysilane is a specialized organosilicon reagent, widely recognized for its role as a versatile protecting group in complex organic synthesis. Its primary value lies in providing selective and stable protection for hydroxyl groups, particularly in the synthesis of sensitive pharmaceutical intermediates and advanced materials. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for multi-step synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for protecting hydroxyl groups during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the production of advanced pesticide and herbicide intermediates requiring selective functional group protection.
• Peptide and Carbohydrate Chemistry: Employed as a silylating agent for the temporary protection of sugar alcohols and amino acids.
• Material Science Research: Serves as a precursor or surface-modifying agent in the development of silicon-based polymers and hybrid materials.
• Asymmetric Synthesis: Utilized in chiral synthesis where the steric bulk of the tert-butyldiphenylsilyl (TBDPS) group provides crucial diastereoselectivity.
• Nucleoside and Oligonucleotide Chemistry: Protects the 5'-hydroxyl group in the synthesis of nucleosides and their analogs.

Basic Information

Product Name	T-Butyldiphenylmethoxysilane
CAS No.	76358-47-9
Molecular Formula	C17H22OSi
Molecular Weight	270.44 g/mol
Synonyms	tert-Butyldiphenylmethoxysilane; tert-Butyl(diphenyl)methoxysilane; Methoxy(tert-butyl)diphenylsilane; TBDPS-OMe; TBDPS Methoxide; Silane, methoxy(1,1-dimethylethyl)diphenyl-; (tert-Butyl)diphenylmethoxysilane
EINECS	Contact for details

Quality Control

Our T-Butyldiphenylmethoxysilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.