Description

Polyphyllin E (Rg) is a bioactive steroidal saponin primarily isolated from the rhizomes of *Paris polyphylla* and related species. This high-purity reference standard is critical for analytical research, quality control, and the development of new therapeutic agents. It serves as an essential material for pharmaceutical R&D, nutraceutical manufacturers, and academic institutions focused on natural product chemistry and pharmacology.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of herbal extracts and finished products in quality control laboratories.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate its reported pharmacological activities, including anti-tumor, anti-inflammatory, and immunomodulatory effects.
• Natural Product Isolation & Analysis: Serves as a critical marker compound for the standardization and authentication of Paris polyphylla extracts in the herbal supplement industry.
• Drug Discovery & Development: Acts as a lead compound or intermediate for the semi-synthesis of novel derivatives with potential enhanced bioactivity or improved pharmacokinetic profiles.
• Academic & Institutional Research: Utilized in universities and research institutes for teaching and advanced studies in phytochemistry, saponin biochemistry, and natural product pharmacology.

Basic Information

Product Name	Polyphyllin E (Rg)
CAS No.	76296-74-7
Molecular Formula	C51H82O21
Molecular Weight	1031.18 g/mol
Synonyms	Polyphyllin Rg; Paris saponin Rg; Pennogenin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-arabinofuranosyl-(1→4)]-β-D-glucopyranoside; Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-arabinofuranosyl-(1→4)]-β-D-glucopyranoside; (25R)-Spirost-5-en-3β-yl O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-arabinofuranosyl-(1→4)]-β-D-glucopyranoside
EINECS	Contact for details

Quality Control

Our Polyphyllin E (Rg) is produced under strict quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment. We support compliance with ISO, GMP, and relevant pharmacopeial guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.