Description

3-Chloro-5-(Trifluoromethyl)Pyridine-2-Thiol is a high-value, multi-functional heterocyclic building block characterized by its reactive thiol and chloro substituents on a pyridine core. This compound matters as a critical intermediate for synthesizing advanced agrochemicals and pharmaceuticals, where its unique trifluoromethyl group enhances biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key precursor for the synthesis of modern pesticides, herbicides, and fungicides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Pharmaceutical Building Block: Used in medicinal chemistry to construct drug candidates targeting various diseases, where the pyridine-thiol scaffold offers versatile modification points.
• Ligand Synthesis: Serves as a starting material for creating complex ligands used in catalysis and material science.
• Functional Material Development: Employed in research for developing advanced polymers, liquid crystals, or electronic materials with specific properties.
• Chemical Research & Development: A versatile reagent for exploring novel synthetic pathways and creating libraries of compounds for screening.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Pyridine-2-Thiol
CAS No.	76041-74-2
Molecular Formula	C6H3ClF3NS
Molecular Weight	213.61 g/mol
Synonyms	2-Mercapto-3-chloro-5-(trifluoromethyl)pyridine; 3-Chloro-5-(trifluoromethyl)-2-pyridinethiol; 3-Chloro-5-(trifluoromethyl)-2-mercaptopyridine; 2-Pyridinethiol, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-5-trifluoromethylpyridine-2-thiol; 76041-74-2; 3-Chloro-5-(trifluoromethyl)-2-thiopyridone (tautomer)
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Pyridine-2-Thiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature and potential for oxidation, it is recommended to handle and store the material under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.