Description

1-(3-(Trifluoromethyl)Phenyl)-1H-Pyrazole-4-Carboxylic Acid CAS NO 75815-75-7 is a high-value, fluorinated pyrazole derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in its trifluoromethylphenyl group, which imparts unique physicochemical properties essential for developing compounds with enhanced metabolic stability and bioavailability. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders and inflammation.
• Agrochemical Active Ingredient Development: Used in research to create new generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand Synthesis for Catalysis: Serves as a precursor for constructing specialized pyrazole-based ligands used in transition metal catalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of advanced polymers and organic electronic materials where the trifluoromethyl group enhances thermal stability and alters electronic properties.
• Chemical Biology & Proteomics: Utilized as a scaffold for designing activity-based probes and molecular tags to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial material supply.

Basic Information

Product Name	1-(3-(Trifluoromethyl)Phenyl)-1H-Pyrazole-4-Carboxylic Acid
CAS No.	75815-75-7
Molecular Formula	C11H7F3N2O2
Molecular Weight	256.18 g/mol
Synonyms	3-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid phenyl ester; 1-[3-(Trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid; 4-Pyrazolecarboxylic acid, 1-[3-(trifluoromethyl)phenyl]-; 1H-Pyrazole-4-carboxylic acid, 1-[3-(trifluoromethyl)phenyl]-; α,α,α-Trifluoro-m-tolyl pyrazole-4-carboxylate; 75815-75-7; 3-Trifluoromethylphenyl pyrazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our production of 1-(3-(Trifluoromethyl)Phenyl)-1H-Pyrazole-4-Carboxylic Acid adheres to stringent quality management systems to ensure batch-to-batch consistency and purity suitable for demanding R&D and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. For projects requiring regulatory support, we can supply material manufactured under quality standards aligned with ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity to moisture (hygroscopic nature).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.