Description

Propionyl-3,3,3-D3 Chloride is a deuterium-labeled derivative of propionyl chloride, a key acylating agent and synthetic intermediate. This compound is specifically valued for its use as a stable isotope-labeled reagent in analytical chemistry and pharmaceutical research, where it serves as a critical internal standard or tracer. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, isotopically labeled building blocks for mass spectrometry, metabolic studies, and the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: As a deuterium-labeled precursor for synthesizing stable isotope-labeled drug candidates and metabolites for pharmacokinetic and metabolic stability studies.
• Analytical Chemistry: Employed as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of propionic acid derivatives and related compounds.
• Agrochemical Synthesis: Used in the development of deuterated pesticides and herbicides to study environmental fate, degradation pathways, and residue analysis.
• Organic Synthesis: Acts as a specialized acylating agent for introducing the propionyl-d3 group into complex molecules under controlled conditions.
• Material Science: Potential use in the synthesis of deuterated polymers or specialty chemicals where isotopic labeling is required to alter material properties or for tracing purposes.

Basic Information

Product Name	Propionyl-3,3,3-D3 Chloride
CAS No.	75695-44-2
Molecular Formula	C3D3ClO
Molecular Weight	109.53 g/mol
Synonyms	Propionyl-d3 Chloride; Deuterated Propionyl Chloride; 3,3,3-Trideuteriopropanoyl Chloride; Propionic-3,3,3-d3 Acid Chloride; CD3CD2C(O)Cl; Propanoyl-3,3,3-d3 Chloride
EINECS	Contact for details

Quality Control

Our Propionyl-3,3,3-D3 Chloride is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, critical for research applications. Each batch is analyzed using advanced techniques including NMR, GC-MS, and IR spectroscopy to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%, atom), chemical purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts violently with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) and handle in a fume hood.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.