Description

Glycochenodeoxycholic Acid-3-o-β-Glucuronide Disodium Salt is a key conjugated bile acid derivative, essential for research into liver metabolism and cholestatic diseases. This high-purity biochemical is critical for developing diagnostic assays and studying the enterohepatic circulation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of in vitro diagnostic (IVD) reagents.

Application

• Biochemical Research: Used as a reference standard and substrate in studies of bile acid metabolism, transport, and signaling pathways.
• Diagnostic Development: Serves as a critical calibrator and control in the manufacturing of ELISA and LC-MS/MS kits for quantifying bile acids in clinical samples.
• Pharmaceutical R&D: Employed in drug discovery programs targeting Farnesoid X Receptor (FXR) and other nuclear receptors involved in metabolic regulation.
• Toxicology Studies: Applied in hepatotoxicity models to investigate mechanisms of drug-induced liver injury (DILI) and cholestasis.
• Cell Culture & In Vitro Assays: Used to modulate bile acid composition in experimental systems to study their effects on cell function and viability.

Basic Information

Product Name	Glycochenodeoxycholic Acid-3-o-β-Glucuronide Disodium Salt
CAS No.	75672-22-9
Molecular Formula	C32H51NNa2O11
Molecular Weight	671.73 g/mol
Synonyms	Glycochenodeoxycholic Acid 3-O-Glucuronide Disodium Salt; GCDCA-3G Na2; 3-O-(β-D-Glucopyranosyluronic acid) Glycochenodeoxycholic Acid Disodium Salt; N-[(3α,5β,7α)-3,7-Dihydroxy-24-oxocholan-24-yl]glycine 3-(β-D-Glucopyranosiduronic Acid) Disodium Salt; Taurochenodeoxycholic Acid 3-Glucuronide Disodium Salt (related); Sodium Glycochenodeoxycholate 3-O-β-D-Glucuronide; Chenodeoxycholylglycine 3-O-β-Glucuronide Disodium Salt
EINECS	Contact for details

Quality Control

Our Glycochenodeoxycholic Acid-3-o-β-Glucuronide Disodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements for research and diagnostic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Tested in relevant assay systems

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.