Description

D-Glucitol-2-D CAS NO 75607-68-0 is a deuterated derivative of D-glucitol (sorbitol), where a hydrogen atom at the 2-position is replaced by deuterium, a stable isotope of hydrogen. This isotopic labeling makes it a crucial tool in advanced research and analytical chemistry, particularly for use as an internal standard in mass spectrometry and NMR spectroscopy. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and analytical reagent sectors who require precise metabolic pathway tracing, pharmacokinetic studies, and high-accuracy quantitative analysis.

Application

• Internal Standard for Mass Spectrometry (MS): Used for the accurate quantification of sorbitol and related metabolites in complex biological matrices like blood, urine, and tissue samples.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a deuterated tracer in metabolic flux analysis and mechanistic studies of biochemical pathways.
• Pharmaceutical Research & Development: Critical in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and excipients.
• Biochemical Research: Employed in enzymatic studies and investigations of the polyol pathway, which is significant in diabetes research.
• Stable Isotope Labeling: Used in the synthesis of more complex deuterated compounds for research purposes.
• Quality Control in Analytical Laboratories: Ensures method validation and accuracy in high-performance liquid chromatography (HPLC) and LC-MS/MS systems.

Basic Information

Product Name	D-Glucitol-2-D
CAS No.	75607-68-0
Molecular Formula	C6H13DO6
Molecular Weight	183.17 g/mol
Synonyms	D-Sorbitol-2-d; (2R)-1-Deoxy-1-(2H)deuterio-D-glucitol; 2-Deuterio-D-glucitol; Sorbitol-2-d; D-Glucitol-2-d1; 2-Deuterosorbitol; Isotopically Labeled Sorbitol; Hexitol-2-d
EINECS	Contact for details

Quality Control

Every batch of D-Glucitol-2-D is produced and analyzed under strict quality management protocols to ensure the highest isotopic and chemical purity for research applications. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic purity (deuterium enrichment), chemical purity by HPLC, and specific identification tests. Our quality system is designed to meet the rigorous standards required for analytical and pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of water vapor, which can affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.