Description

Morphine 6-Nicotinate is a specialized morphine derivative where a nicotinic acid moiety is esterified at the 6-hydroxy position. This chemical modification is of significant interest in pharmaceutical research for creating novel prodrugs and exploring structure-activity relationships of opioid analgesics. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical suppliers engaged in advanced medicinal chemistry and neuropharmacology studies.

Application

• Pharmaceutical Research & Development: A key intermediate for synthesizing novel morphine analogs and prodrug candidates to modulate pharmacokinetic properties.
• Medicinal Chemistry Studies: Used to investigate the structure-activity relationship (SAR) of opioid receptor ligands and the impact of esterification on potency and selectivity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in forensic and pharmaceutical analysis.
• Biochemical Research: Employed in in vitro studies to understand metabolic pathways and enzymatic hydrolysis of ester-linked opioid derivatives.
• Precursor for Specialty Chemicals: Used in the synthesis of more complex, targeted chemical entities for specialized pharmacological screening.

Basic Information

Product Name	Morphine 6-Nicotinate
CAS No.	75533-60-7
Molecular Formula	C28H26N2O5
Molecular Weight	470.52 g/mol
Synonyms	Morphine 6-nicotinate; 6-O-Nicotinoylmorphine; Morphin-6-yl nicotinate; 7,8-Didehydro-4,5α-epoxy-17-methylmorphinan-3,6α-diol 6-nicotinate; Nicotinic acid morphin-6-yl ester
EINECS	Contact for details

Quality Control

Our Morphine 6-Nicotinate is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.