Description

1-Boc-Indole is a protected derivative of indole, featuring a tert-butoxycarbonyl (Boc) group on the nitrogen atom, which serves as a crucial protective group in synthetic organic chemistry. This compound is highly valued for its role in facilitating complex multi-step syntheses by safeguarding the reactive indole nitrogen during reactions at other sites. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of drug candidates, especially those containing indole scaffolds such as kinase inhibitors and serotonin receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides.
• Peptide Chemistry: Serves as a protected precursor for introducing tryptophan analogs or other indole-containing structures into peptides.
• Material Science Research: Employed in the development of organic semiconductors and functional dyes.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Product Name	1-Boc-Indole
CAS No.	75400-67-8
Molecular Formula	C₁₃H₁₅NO₂
Molecular Weight	217.26 g/mol
Synonyms	1-(tert-Butoxycarbonyl)indole; N-Boc-indole; tert-Butyl 1H-indole-1-carboxylate; Indole-1-carboxylic acid tert-butyl ester; 1H-Indole-1-carboxylic acid, 1,1-dimethylethyl ester; Boc-Indole; N-tert-Butoxycarbonylindole; 1-Boc-1H-indole
EINECS	Contact for details

Quality Control

Our 1-Boc-Indole is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters. We support cGMP standards for applications requiring the highest level of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.