Description

1H-Pyrrolo[1,2-C]Imidazole-1,3(2H)-Dione,Tetrahydro-6-Hydroxy-,(6R-Trans)-(9Ci) is a high-purity chiral heterocyclic compound with significant synthetic utility. This advanced pharmaceutical intermediate is valued for its role in constructing complex molecular architectures, particularly in active pharmaceutical ingredient (API) development. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel APIs, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce complex fused-ring systems with defined stereochemistry.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in route scouting and scale-up studies for the commercial manufacturing of complex drug candidates.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Fine Chemical Synthesis: A precursor for synthesizing specialized ligands, catalysts, and other high-value fine chemicals.

Basic Information

Product Name	1H-Pyrrolo[1,2-C]Imidazole-1,3(2H)-Dione,Tetrahydro-6-Hydroxy-,(6R-Trans)-(9Ci)
CAS No.	75281-55-9
Molecular Formula	C7H8N2O3
Molecular Weight	168.15 g/mol
Synonyms	(6R)-6-Hydroxyhexahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione; Tetrahydro-6-hydroxy-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione, (6R-trans)-; (6R)-6-Hydroxy-1,2,3,5,6,7-hexahydro-1H-pyrrolo[1,2-c]imidazole-1,3-dione; 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione, tetrahydro-6-hydroxy-, (6R-trans)-; 75281-55-9; (6R)-Hexahydro-6-hydroxy-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[1,2-C]Imidazole-1,3(2H)-Dione,Tetrahydro-6-Hydroxy-,(6R-Trans)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.