Description

n-(6-Aminohexyl)Maleimide Hydrochloride Salt is a heterobifunctional crosslinking reagent featuring a maleimide group and a primary amine, separated by a six-carbon spacer arm. This compound is essential for creating stable, covalent bonds between thiol-containing molecules (like proteins or peptides) and amine-reactive surfaces or other biomolecules. It is a critical intermediate in bioconjugation, particularly for the development of antibody-drug conjugates (ADCs), diagnostic assays, and immobilized enzyme systems. Researchers and manufacturers in the pharmaceutical, biotechnology, and life science reagent sectors rely on its precise reactivity for advanced therapeutic and diagnostic platforms.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic drugs to monoclonal antibodies.
• Protein and Peptide Labeling: Used to conjugate fluorescent dyes, biotin, or other reporter molecules to cysteine residues in proteins for imaging and detection.
• Surface Immobilization: Functionalizes gold surfaces, chips, or beads with maleimide groups for the specific capture of thiolated biomolecules in biosensor and microarray development.
• Polymer Modification: Incorporates into polymer backbones or dendrimers to introduce reactive sites for further bioconjugation, creating smart drug delivery systems.
• Enzyme Stabilization: Facilitates the site-specific crosslinking or immobilization of enzymes, enhancing their stability and reusability in industrial biocatalysis.
• Diagnostic Reagent Development: Employed in the manufacture of conjugated antigens or antibodies for ELISA, lateral flow assays, and other immunodiagnostic tests.

Basic Information

Product Name	n-(6-Aminohexyl)Maleimide Hydrochloride Salt
CAS No.	75238-09-4
Molecular Formula	C10H17ClN2O2
Molecular Weight	232.71 g/mol
Synonyms	6-Maleimidohexylamine hydrochloride; N-(6-Aminohexyl)maleimide HCl; 1-(6-Aminohexyl)-1H-pyrrole-2,5-dione hydrochloride; AHM hydrochloride; Maleimidocaproic acid amide hydrochloride; N-(6-Amino-n-hexyl)maleimide hydrochloride; 6-Maleimidocaproamide hydrochloride
EINECS	Contact for details

Quality Control

Our n-(6-Aminohexyl)Maleimide Hydrochloride Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.