Description

3-Hydroxybutorphanol is a key pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is primarily utilized in the synthesis and analytical characterization of butorphanol-related substances, which are critical in the pharmaceutical sector. It serves as an essential building block for researchers and manufacturers in the pharmaceutical and fine chemical industries who require high-purity intermediates for advanced drug development and quality control processes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of butorphanol and its related analgesic compounds.
• Analytical Reference Standard: Used for method development, validation, and quality control testing in pharmaceutical laboratories.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research for butorphanol.
• Impurity Profiling: Serves as a known impurity or degradation product standard to ensure drug substance purity.
• Research & Development: A vital tool in medicinal chemistry for the development of new opioid receptor modulators.
• GMP Manufacturing: Used in the production of active pharmaceutical ingredients (APIs) under controlled, high-quality conditions.

Basic Information

Product Name	3-Hydroxybutorphanol
CAS No.	75195-49-2
Molecular Formula	C21H29NO2
Molecular Weight	327.47 g/mol
Synonyms	3-Hydroxybutorphanol; 17-(Cyclobutylmethyl)morphinan-3,14-diol; Butorphanol Impurity; Butorphanol Related Compound; 3-Hydroxybutorphanol Tartrate (Salt); (-)-3-Hydroxybutorphanol; Morphinan-3,14-diol, 17-(cyclobutylmethyl)-, (5α,6α)-; 75195-49-2
EINECS	Contact for details

Quality Control

Our 3-Hydroxybutorphanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with GMP, ICH Q7, and other relevant pharmaceutical guidelines for intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.