Description

1-(2-Chloroethyl)-4-Iodobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional structure, featuring both a reactive chloroethyl side chain and an iodine substituent on the benzene ring, makes it a critical precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in cross-coupling reactions and as a key intermediate in active ingredient development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators, leveraging its halogenated structure for further functionalization.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Cross-Coupling Reactions: The iodine atom is highly reactive in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) for carbon-carbon bond formation.
• Ligand and Catalyst Development: Utilized to synthesize complex chelating ligands for metal catalysts used in asymmetric synthesis and industrial catalysis.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	1-(2-Chloroethyl)-4-Iodobenzene
CAS No.	75067-07-1
Molecular Formula	C8H8ClI
Molecular Weight	266.51 g/mol
Synonyms	4-(2-Chloroethyl)iodobenzene; 1-Chloro-2-(4-iodophenyl)ethane; p-Iodophenethyl chloride; (4-Iodophenyl)ethyl chloride; 2-(4-Iodophenyl)ethyl chloride; 75067-07-1; 4-Iodophenethyl chloride; 1-(4-Iodophenyl)-2-chloroethane
EINECS	Contact for details

Quality Control

Our 1-(2-Chloroethyl)-4-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.