Description

2-Bromocyclobutanone is a versatile brominated cyclic ketone building block essential for advanced organic synthesis. Its unique structure, featuring a reactive carbonyl group adjacent to a bromine-substituted four-membered ring, makes it a critical intermediate for constructing strained and complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as ring-expansion reactions, cross-coupling precursors, and the synthesis of novel heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) and bioactive molecules, particularly those containing cyclobutane or strained ring systems.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides by serving as a precursor for functionalized cyclic compounds.
• Material Science: Employed in the synthesis of specialty polymers, ligands, and organic frameworks where the cyclobutanone moiety imparts specific physical or chemical properties.
• Organic Synthesis Building Block: Facilitates various transformations including nucleophilic substitution, ring-opening, and [2+2] cycloaddition reactions to access diverse chemical space.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for carbon-carbon bond formation, leveraging the bromine atom as a handle.
• Academic & R&D: A valuable reagent for methodological development and exploring new reaction pathways in university and industrial research laboratories.

Basic Information

Product Name	2-Bromocyclobutanone
CAS No.	1192-01-4
Molecular Formula	C4H5BrO
Molecular Weight	149.00 g/mol
Synonyms	2-Bromocyclobutan-1-one; α-Bromocyclobutanone; Cyclobutanone, 2-bromo-; Bromocyclobutanone; 2-Bromo-1-cyclobutanone; 1-Cyclobutanone, 2-bromo-; NSC 406906
EINECS	214-761-6

Quality Control

Our 2-Bromocyclobutanone is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature and reactivity, it is recommended to handle under an inert atmosphere for extended storage periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.