Description

2-(2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl)-Isoindole-1,3-Dione is a specialized chemical intermediate featuring a hydrophilic polyethylene glycol (PEG) spacer linked to a phthalimide group. This unique structure makes it a valuable building block for the synthesis of functionalized polymers, prodrugs, and advanced materials. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, polymer science, and specialty chemical industries for creating compounds with tailored solubility and reactivity profiles.

Application

• Pharmaceutical Intermediate: Key starting material or linker for the synthesis of prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutics, leveraging its PEG moiety for enhanced solubility.
• Polymer Modification: Used to introduce phthalimide-protected amine functionalities or hydrophilic PEG chains into polymers, resins, and dendrimers.
• Surface Functionalization: Employed in modifying material surfaces (e.g., nanoparticles, silica) to create reactive sites for further bioconjugation or to impart hydrophilicity.
• Crosslinking Agent: Serves as a heterobifunctional crosslinker in material science and bioconjugation applications due to its distinct reactive ends.
• Organic Synthesis Building Block: Provides a protected amine precursor (after deprotection) for the synthesis of complex organic molecules, peptides, and peptidomimetics.
• Ligand and Catalyst Design: Utilized in the development of novel ligands and catalysts where a tunable, water-soluble spacer is required.

Basic Information

Product Name	2-(2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl)-Isoindole-1,3-Dione
CAS No.	75001-08-0
Molecular Formula	C₁₆H₂₁NO₆
Molecular Weight	323.34 g/mol
Synonyms	2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethyl]-1H-isoindole-1,3(2H)-dione; N-(2-[2-(2-Hydroxyethoxy)ethoxy]ethyl)phthalimide; Phthalimide PEG2 alcohol; Phthalimide-PEG2-OH; 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethyl)isoindoline-1,3-dione; N-PEG2-phthalimide alcohol; Fmoc-PEG2-phthalimide precursor (related); Hydroxy-PEG2-phthalimide
EINECS	Contact for details

Quality Control

Every batch of 2-(2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethyl)-Isoindole-1,3-Dione is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and commercial scale applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity (IR, NMR), and specific tests is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.