Description

2-Amino-3-O,4-O,5-O,6-o-Tetrakis(Trimethylsilyl)-2-Deoxy-D-Glucose is a sophisticated, fully protected derivative of the fundamental sugar D-glucose, featuring amino and multiple trimethylsilyl (TMS) ether groups. This compound is a critical high-purity synthetic intermediate for the controlled construction of complex carbohydrate molecules and glycoconjugates. It is essential for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of nucleoside analogs, glycomimetics, and other bioactive compounds where precise stereochemistry and protecting group strategy are paramount.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel nucleoside-based antiviral or anticancer agents.
• Glycochemistry Research: Used as a protected glycosyl donor or acceptor for the controlled synthesis of oligosaccharides and complex glycans.
• Glycomimetic Development: Serves as a precursor for creating stable sugar analogs that mimic natural carbohydrates for drug discovery.
• Chemical Biology Probes: Enables the preparation of labeled or modified sugars for studying carbohydrate-protein interactions and metabolic pathways.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for carbohydrate-active active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies in carbohydrate chemistry and medicinal chemistry.

Basic Information

Product Name	2-Amino-3-O,4-O,5-O,6-o-Tetrakis(Trimethylsilyl)-2-Deoxy-D-Glucose
CAS No.	74978-27-1
Molecular Formula	C18H45NO5Si4
Molecular Weight	491.90 g/mol
Synonyms	2-Amino-2-deoxy-3,4,5,6-tetra-O-(trimethylsilyl)-D-glucose; 2-Amino-2-deoxy-D-glucose tetrakis(trimethylsilyl) ether; D-Glucose, 2-amino-2-deoxy-, 3,4,5,6-tetra-O-(trimethylsilyl)-; 2-Deoxy-2-amino-3,4,5,6-tetra-O-trimethylsilyl-D-glucopyranose; TMS-protected D-glucosamine derivative; Fully silylated D-glucosamine; Per-O-TMS glucosamine
EINECS	Contact for details

Quality Control

Our 2-Amino-3-O,4-O,5-O,6-o-Tetrakis(Trimethylsilyl)-2-Deoxy-D-Glucose is produced under controlled conditions to ensure high chemical purity and lot-to-lot consistency, suitable for demanding synthetic applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.