Description

Acetamidine-D3 Hydrochloride is a deuterium-labeled isotopologue of acetamidine hydrochloride, a key building block in organic synthesis and medicinal chemistry. This high-purity compound is essential for creating stable isotope-labeled analogs for use in mass spectrometry and pharmacokinetic studies. It is primarily utilized by pharmaceutical researchers, agrochemical developers, and contract research organizations (CROs) engaged in drug discovery and metabolic pathway analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative standard in bioanalytical methods for measuring drug and metabolite concentrations in biological matrices.
• Metabolic Studies: Used in the synthesis of deuterated drug candidates to study absorption, distribution, metabolism, and excretion (ADME) profiles.
• Mechanistic Research: A valuable tool for tracing reaction pathways and investigating biochemical mechanisms without significant isotopic effect interference.
• Pharmaceutical Intermediate: Acts as a labeled precursor in the synthesis of more complex deuterated active pharmaceutical ingredients (APIs).
• Proteomics & Biomarker Research: Employed in quantitative proteomics for accurate peptide and protein quantification.

Basic Information

Product Name	Acetamidine-D3 Hydrochloride
CAS No.	74929-88-7
Molecular Formula	C2D3H3N2•HCl
Molecular Weight	101.56 g/mol
Synonyms	Acetamidine-d3 hydrochloride; Ethanimidamide-d3 hydrochloride; 1,1,1-Trideuteroacetamidine hydrochloride; Acetamidine-1,1,1-d3 hydrochloride; Deuterated acetamidine HCl; (1,1,1-2H3)Acetamidine hydrochloride; Acetimidamide-d3 hydrochloride
EINECS	Contact for details

Quality Control

Our Acetamidine-D3 Hydrochloride is manufactured under strict quality control protocols to ensure high isotopic purity and chemical purity suitable for sensitive analytical applications. Each batch is analyzed by NMR and mass spectrometry to confirm deuteration level and identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.