Description

(1As,8R,8Ar,8Bs)-6-Amino-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-8A-Methoxy-1,5-Dimethylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione is a complex heterocyclic compound featuring a unique azirino-pyrrolo-indole tricyclic core structure. This molecule is of significant interest in advanced pharmaceutical research and development, particularly as a sophisticated synthetic intermediate or a potential pharmacophore. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, especially in oncology and antibiotic discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Oncology Research: Investigated as a core scaffold or precursor for developing novel antitumor and anticancer agents due to its intricate, biologically relevant structure.
• Antibiotic Development: Used in research programs aimed at creating new classes of antibiotics, leveraging its fused indole and aziridine motifs.
• Medicinal Chemistry: Employed as a key intermediate for structure-activity relationship (SAR) studies and lead optimization in drug discovery pipelines.
• Biochemical Research: Utilized as a tool compound or a specialty reagent in biochemical assays and mechanism-of-action studies.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for high-value fine chemicals.

Basic Information

Product Name	(1As,8R,8Ar,8Bs)-6-Amino-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-8A-Methoxy-1,5-Dimethylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione
CAS No.	74707-94-1
Molecular Formula	C19H22N4O6
Molecular Weight	402.41 g/mol
Synonyms	6-Amino-8-[(aminocarbonyl)oxymethyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione derivative; Mitomycin derivative analog; Antibiotic analog intermediate; NSC 710305; U-63,366; Compound 74707-94-1
EINECS	Contact for details

Quality Control

Our production of this high-purity research chemical adheres to strict quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.