Description

1-(tert-Butyldimethylsilyloxy)-2-Propanone is a versatile silyl-protected ketone reagent, widely recognized for its role as a key synthetic intermediate in advanced organic synthesis. Its primary value lies in providing a protected hydroxyl functionality that is stable under a wide range of reaction conditions, enabling complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the production of active pharmaceutical ingredients (APIs) and complex natural products.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug molecules, especially those requiring selective protection and deprotection strategies.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific functional group manipulation is required.
• Fine Chemical Manufacturing: Serves as a precursor for fragrances, flavors, and other specialty chemicals requiring high-purity intermediates.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and for constructing molecular libraries.
• Peptide & Carbohydrate Chemistry: Employed in the protection of hydroxyl groups during the synthesis of complex biomolecules.
• Material Science Precursor: Can be utilized in the development of novel silicon-containing polymers and hybrid materials.

Basic Information

Item	Details
Product Name	1-(tert-Butyldimethylsilyloxy)-2-Propanone
CAS No.	74685-00-0
Molecular Formula	C9H20O2Si
Molecular Weight	188.34 g/mol
Synonyms	Acetone O-(tert-Butyldimethylsilyl) Oxime; 2-Propanone, 1-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-; 1-(TBDMSO)-2-Propanone; 1-Hydroxy-2-propanone tert-butyldimethylsilyl ether; O-(tert-Butyldimethylsilyl)hydroxyacetone; Acetol TBDMS ether; TBDMS-protected hydroxyacetone
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyldimethylsilyloxy)-2-Propanone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP standards where applicable to meet the stringent requirements of our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.