Description

(1-Methylethyl)Chloridophosphonous Acid [5-Methyl-2-(1-Methylethyl)Cyclohexyl] Ester is a specialized organophosphorus compound featuring a menthol-derived chiral scaffold. This structure matters for its utility as a key chiral intermediate or ligand in asymmetric synthesis, enabling the production of high-value, enantiomerically pure compounds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with precise stereochemistry.

Application

• Chiral Ligand in Asymmetric Catalysis: Acts as a phosphorus-based ligand for transition metal catalysts in enantioselective hydrogenation, hydroformylation, or cross-coupling reactions.
• Intermediate for Pharmaceutical Actives: Serves as a building block in the synthesis of chiral active pharmaceutical ingredients (APIs), particularly those requiring a menthol-like backbone.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure pesticides and herbicides, where specific stereochemistry is crucial for bioactivity.
• Material Science Precursor: Potential monomer or additive in the development of specialty polymers with tailored properties.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for methodological studies in organophosphorus chemistry and stereochemistry.

Basic Information

Product Name	(1-Methylethyl)Chloridophosphonous Acid [5-Methyl-2-(1-Methylethyl)Cyclohexyl] Ester
CAS No.	74630-89-0
Molecular Formula	C13H26ClOP
Molecular Weight	264.77 g/mol
Synonyms	Isopropyl Chloro(menthyl)phosphonite; Chloro(isopropyl)((1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl)phosphane; Menthyl Isopropylchlorophosphonite; (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Chloro(1-methylethyl)phosphonite; (-)-Menthyl Isopropylchlorophosphonite; Phosphonous acid, chloro(1-methylethyl)-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
EINECS	Contact for details

Quality Control

Our production of (1-Methylethyl)Chloridophosphonous Acid [5-Methyl-2-(1-Methylethyl)Cyclohexyl] Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high chiral purity. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.