Description

4-Hydroxy-3-Methoxybenzaldehyde-D3 is a deuterated analog of vanillin, a key flavor and fragrance compound, where three hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for advanced analytical applications, providing an internal standard for precise quantification and metabolic pathway tracing. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in mass spectrometry, NMR spectroscopy, and pharmacokinetic studies.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical reference standard in GC-MS and LC-MS methods for the accurate measurement of vanillin and related metabolites in complex matrices.
• Metabolic and Pharmacokinetic Studies: Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of vanillin and its derivatives in biological systems.
• NMR Spectroscopy: Acts as a valuable probe in nuclear magnetic resonance studies due to the distinct magnetic properties of deuterium, aiding in structural elucidation and dynamic analysis.
• Flavor and Fragrance Research: Enables precise, isotope-dilution analysis of vanillin content and authenticity testing in food products, beverages, and perfumes.
• Pharmaceutical Impurity Profiling: Supports the identification and quantification of process-related impurities and degradation products in drug formulations containing vanillin derivatives.

Basic Information

Product Name	4-Hydroxy-3-Methoxybenzaldehyde-D3
CAS No.	74495-74-2
Molecular Formula	C8H5D3O3
Molecular Weight	155.17 g/mol
Synonyms	Vanillin-d3; 3-Methoxy-4-hydroxybenzaldehyde-d3; Deuterated Vanillin; Vanillin (ring-D3); 4-Hydroxy-3-methoxybenzaldehyde (ring-D3); Benzaldehyde, 4-hydroxy-3-methoxy-(ring-D3); (2,3,6-D3)Vanillin
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-Methoxybenzaldehyde-D3 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and identity is provided to guarantee consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 99.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.