Description

Homovanillic Acid-D3 is a stable isotope-labeled analog of homovanillic acid, where three hydrogen atoms are replaced by deuterium. This compound is essential as a high-purity internal standard for the accurate quantification of homovanillic acid in complex biological matrices using mass spectrometry. It is primarily required by analytical laboratories, clinical research facilities, and pharmaceutical companies engaged in neurochemical research, metabolic disorder studies, and drug development.

Application

• Internal Standard for LC-MS/MS: Critical for precise quantification of endogenous homovanillic acid in plasma, urine, and cerebrospinal fluid.
• Biomarker Research: Used in studies of dopamine metabolism, neurological disorders (e.g., Parkinson's disease), and psychiatric conditions.
• Clinical Diagnostics: Supports the development and validation of robust diagnostic assays for catecholamine pathway analysis.
• Pharmaceutical R&D: Enables pharmacokinetic and metabolomic studies for drugs affecting the dopaminergic system.
• Forensic Toxicology: Aids in the accurate detection and measurement of dopamine-related metabolites in forensic samples.
• Quality Control Reference: Serves as a certified reference material (CRM) for ensuring the accuracy of in-house laboratory methods.

Basic Information

Product Name	Homovanillic Acid-D3
CAS No.	74495-71-9
Molecular Formula	C9H7D3O4
Molecular Weight	185.19 g/mol
Synonyms	4-Hydroxy-3-methoxybenzeneacetic-2,2,2-d3 acid; 3-Methoxy-4-hydroxyphenylacetic-2,2,2-d3 acid; HVA-d3; Deuterated Homovanillic Acid; 2-(4-Hydroxy-3-methoxyphenyl)acetic-2,2,2-d3 acid; 4-Hydroxy-3-methoxy-d3-phenylacetic acid; Homovanillic Acid (deuterated, 2,2,2-d3)
EINECS	Contact for details

Quality Control

Every batch of Homovanillic Acid-D3 is produced and analyzed under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.