Description

(+/-)-Vanilmandelic-D3 Acid CAS NO 74495-70-8 is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in clinical and research settings. Its primary value lies in enabling precise measurement of endogenous vanilmandelic acid (VMA) levels via mass spectrometry, a key diagnostic tool. This compound is essential for laboratories in the pharmaceutical, clinical diagnostics, and biomedical research sectors, particularly those developing and validating assays for neuroendocrine tumors and catecholamine metabolism disorders.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of vanilmandelic acid (VMA) in biological matrices like urine and plasma.
• Clinical Diagnostics: Critical for assay development and validation in the diagnosis and monitoring of neuroendocrine tumors, such as pheochromocytoma and neuroblastoma.
• Biomedical Research: Enables accurate study of catecholamine metabolism pathways and related disorders in academic and institutional research.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetic (DMPK) studies for compounds affecting the sympathetic nervous system.
• Quality Control in Testing Kits: Incorporated into commercial diagnostic test kits and calibrators to ensure assay accuracy and reproducibility.
• Forensic Toxicology: Aids in the specific detection and quantification of catecholamine metabolites in forensic analyses.

Basic Information

Product Name	(+/-)-Vanilmandelic-D3 Acid
CAS No.	74495-70-8
Molecular Formula	C9H6D3O5
Molecular Weight	201.18 g/mol (approximate)
Synonyms	VMA-d3; 3-Methoxy-4-hydroxymandelic-d3 Acid; 4-Hydroxy-3-methoxymandelic-d3 Acid; DL-3-Methoxy-4-hydroxymandelic-d3 Acid; (±)-Vanilmandelic-d3 Acid; 3-O-Methyl-d3 Vanillylmandelic Acid; Deuterated Vanillylmandelic Acid; HMMA-d3
EINECS	Contact for details

Quality Control

Every batch of our (+/-)-Vanilmandelic-D3 Acid is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for critical analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and identity confirmation is provided with each shipment to ensure full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.