Description

2-Chloro-4-(4-Fluorophenyl)-5-Thiazolecarboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its precise molecular architecture, which serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific thiazole and fluorophenyl motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole core.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, or functional polymers with tailored properties.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the development of chemical probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	2-Chloro-4-(4-Fluorophenyl)-5-Thiazolecarboxylic Acid Ethyl Ester
CAS No.	74476-51-0
Molecular Formula	C₁₂H₉ClFNO₂S
Molecular Weight	285.72 g/mol
Synonyms	Ethyl 2-Chloro-4-(4-fluorophenyl)thiazole-5-carboxylate; 2-Chloro-4-(p-fluorophenyl)-5-thiazolecarboxylic Acid Ethyl Ester; 5-Thiazolecarboxylic acid, 2-chloro-4-(4-fluorophenyl)-, ethyl ester; Ethyl 2-chloro-4-(4-fluorophenyl)-1,3-thiazole-5-carboxylate; 74476-51-0; 2-Chloro-4-(4-fluorophenyl)thiazole-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-4-(4-Fluorophenyl)-5-Thiazolecarboxylic Acid Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and purity verification. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.