Description

Ethyl 1-(Ethoxycarbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-acetate hydrochloride is a high-purity, complex heterocyclic compound that serves as a critical advanced intermediate in modern pharmaceutical synthesis. Its precise molecular architecture makes it an essential building block for developing innovative active pharmaceutical ingredients (APIs), particularly in neurological and psychiatric research. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel central nervous system (CNS) active drugs and other therapeutic agents.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), where its specific indole and piperidine fused structure is incorporated into the final molecule.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in scale-up and process optimization for the commercial manufacturing of target drug candidates.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in regulatory filings.

Basic Information

Product Name	Ethyl 1-(Ethoxycarbonyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-1-Acetate Hydrochloride
CAS No.	74406-12-5
Molecular Formula	C20H24N2O4 · HCl
Molecular Weight	392.88 g/mol (free base: 356.42 g/mol)
Synonyms	1H-Pyrido[3,4-b]indole-1-acetic acid, 2,3,4,9-tetrahydro-1-(ethoxycarbonyl)-, ethyl ester, hydrochloride; Ethyl 1-carbethoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-acetate hydrochloride; Tryptophan derivative hydrochloride; Ethyl ester of a tetrahydro-β-carboline carboxylic acid hydrochloride; Advanced indole alkaloid intermediate.
EINECS	Contact for details

Quality Control

Every batch of Ethyl 1-(Ethoxycarbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-acetate hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and mass spectrometry is supplied with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.