Description

5-Methyl-1-(Trimethylsilyl)-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is a specialized organosilicon-protected derivative of indole-3-acetic acid, a key structural motif in bioactive chemistry. This compound is engineered to provide enhanced stability and solubility for advanced synthetic applications, particularly in protecting sensitive functional groups during complex multi-step reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key protected synthon for the synthesis of novel indole-based drug candidates, including potential kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in developing new plant growth regulators and protective agents by leveraging the indole acetic acid backbone.
• Organic Synthesis Building Block: The dual trimethylsilyl (TMS) protection allows for selective deprotection strategies, making it valuable for constructing complex heterocyclic systems.
• Material Science Precursor: Serves as a starting material for synthesizing functionalized organic semiconductors or ligands for catalytic systems.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new synthetic pathways involving sensitive indole derivatives.

Basic Information

Product Name	5-Methyl-1-(Trimethylsilyl)-1H-Indole-3-Acetic Acid Trimethylsilyl Ester
CAS No.	74367-50-3
Molecular Formula	C₁₇H₂₇NO₂Si₂
Molecular Weight	333.58 g/mol
Synonyms	1H-Indole-3-acetic acid, 5-methyl-1-(trimethylsilyl)-, trimethylsilyl ester; 5-Methyl-1-TMS-indole-3-acetic acid TMS ester; 3-(Trimethylsilyloxymethyl)-5-methyl-1-(trimethylsilyl)indole; 5-Methyl-1-(trimethylsilyl)indol-3-ylmethyl trimethylsilyl ether; TMS-IAA-TMS Ester; 74367-50-3; 5-Methyl-1-(trimethylsilyl)-1H-indole-3-acetic acid TMS ester
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-1-(Trimethylsilyl)-1H-Indole-3-Acetic Acid Trimethylsilyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.