Description

(Rs)-2,2-Dimethyl-1,3-Dioxolane-4-Methanol-D5 is a deuterated isotopologue of the chiral building block solketal, where five hydrogen atoms are replaced by deuterium. This compound matters for its role as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring precise and reliable analytical measurements. It is primarily needed by pharmaceutical research and development laboratories, analytical chemistry service providers, and manufacturers of advanced organic materials who require high-fidelity isotopic tracers for metabolic studies, pharmacokinetics, and reaction mechanism elucidation.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of solketal or related metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies as a non-radioactive tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Synthetic Chemistry Probe: Employed in mechanistic studies to trace the fate of specific molecular fragments during chemical reactions, leveraging the kinetic isotope effect.
• Analytical Reference Standard: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating methods in compliance with GLP and GMP guidelines.
• Metabolomics and Biomarker Discovery: Facilitates precise relative and absolute quantification in untargeted and targeted metabolomic profiling.
• Production of Labeled Fine Chemicals: Acts as a deuterated precursor for the synthesis of more complex isotopically labeled compounds used in various research fields.

Basic Information

Product Name	(Rs)-2,2-Dimethyl-1,3-Dioxolane-4-Methanol-D5
CAS No.	74300-14-4
Molecular Formula	C6H6D5O3
Molecular Weight	137.18 g/mol
Synonyms	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol-d5; (R)-(-)-1,2-Isopropylidene Glycerol-d5; (R)-(-)-Solketal-d5; (R)-(-)-1,2-O-Isopropylidene Glycerol-d5; (R)-2,2-Dimethyl-1,3-dioxolan-4-yl-methanol-d5; (R)-Glycerol Acetonide-d5; (R)-1,2-Acetonide Glycerol-d5; (3R)-2,2-Dimethyl-1,3-dioxolan-4-ylmethanol-d5
EINECS	Contact for details

Quality Control

Every batch of our (Rs)-2,2-Dimethyl-1,3-Dioxolane-4-Methanol-D5 is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for use as an analytical standard. Certificates of Analysis (COA) are provided with each shipment, detailing results from NMR (for deuterium incorporation), HPLC, and GC analyses. Our quality commitment ensures reliable batch-to-batch consistency and traceability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use to prevent evaporation and potential concentration changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Optical Rotation	[α]D20 -14.0° to -16.0° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.