Description

[[1-Methoxyestra-1,3,5(10)-Triene-3,17β-Diyl]Bis(Oxy)]Bis(Trimethylsilane) is a high-purity, advanced steroid intermediate featuring protective silyl ether groups, which are critical for complex synthetic pathways. This compound matters for its role in enabling precise and efficient chemical transformations in the production of specialized pharmaceutical actives and research compounds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for synthesizing novel steroid-based therapeutics and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of novel steroid-based drug candidates and active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial laboratories for investigating steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Process Chemistry: Serves as a protected intermediate in scalable process development for steroid manufacturing, where the trimethylsilyl (TMS) groups offer temporary protection of hydroxyl functions.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in steroid analysis.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, high-value steroid derivatives for specialized applications.

Basic Information

Product Name	[[1-Methoxyestra-1,3,5(10)-Triene-3,17β-Diyl]Bis(Oxy)]Bis(Trimethylsilane)
CAS No.	74299-25-5
Molecular Formula	C25H42O3Si2
Molecular Weight	446.78 g/mol
Synonyms	3,17β-Bis(trimethylsilyloxy)-1-methoxyestra-1,3,5(10)-triene; 1-Methoxyestra-1,3,5(10)-triene-3,17β-diol bis(trimethylsilyl) ether; Estra-1,3,5(10)-triene-3,17-diol, 1-methoxy-, 3,17-bis(trimethylsilyl) ether; 1-Methoxyestradiol 3,17-bis-TMS ether; 1-Methoxyestra-1,3,5(10)-triene-3,17β-diol bis(TMS) ether; 1-MeO-E2 bis(trimethylsilyl ether); 1-Methoxyestradiol bis(trimethylsilyl) ether; 3,17β-Bis-O-(trimethylsilyl)-1-methoxyestra-1,3,5(10)-triene
EINECS	Contact for details

Quality Control

Our [[1-Methoxyestra-1,3,5(10)-Triene-3,17β-Diyl]Bis(Oxy)]Bis(Trimethylsilane) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.