Description

1,2,3,4-Tetrahydro-2-(Trifluoroacetyl)Isoquinoline-7-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride group and trifluoroacetyl moiety. This compound is essential for introducing the isoquinoline scaffold and sulfonamide functionality into target molecules with enhanced lipophilicity and metabolic stability. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with improved efficacy.
• Chemical Biology Probe Development: Serves as a precursor for creating activity-based probes to study enzyme function and mechanism.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with specific electronic properties.
• Sulfonamide Library Synthesis: A critical reagent for parallel and combinatorial chemistry to generate diverse sulfonamide-based compound libraries for high-throughput screening.

Basic Information

Product Name	1,2,3,4-Tetrahydro-2-(trifluoroacetyl)isoquinoline-7-sulfonyl chloride
CAS No.	74291-57-9
Molecular Formula	C₁₁H₉F₃NO₃S
Molecular Weight	292.25 g/mol
Synonyms	7-(Chlorosulfonyl)-1,2,3,4-tetrahydro-2-(trifluoroacetyl)isoquinoline; 2-(Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride; 1,2,3,4-Tetrahydro-2-(trifluoroacetyl)-7-isoquinolinesulfonyl chloride; Isoquinoline-7-sulfonyl chloride, 1,2,3,4-tetrahydro-2-(trifluoroacetyl)-; 74291-57-9
EINECS	Contact for details

Quality Control

Our production of 1,2,3,4-Tetrahydro-2-(Trifluoroacetyl)Isoquinoline-7-Sulfonyl Chloride adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is fully characterized and tested against comprehensive specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.