Description

[S,(-)]-1,2-Dichloropropane CAS NO 74282-28-3 is a high-purity chiral isomer of 1,2-dichloropropane, serving as a critical building block in advanced organic synthesis. Its defined stereochemistry is essential for producing enantiomerically pure compounds, where the spatial arrangement of atoms directly influences biological activity and material properties. This specialty chemical is primarily required by the pharmaceutical, agrochemical, and fine chemical industries for the development of active ingredients, chiral catalysts, and high-value intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Fine Chemical Manufacturing: Employed as a precursor for chiral ligands, catalysts, and other high-value specialty chemicals.
• Asymmetric Synthesis: Serves as a starting material or reagent in stereoselective reactions to construct complex molecular architectures.
• Material Science Research: Utilized in the development of chiral polymers and advanced materials with specific optical properties.

Basic Information

Product Name	[S,(-)]-1,2-Dichloropropane
CAS No.	74282-28-3
Molecular Formula	C3H6Cl2
Molecular Weight	112.99 g/mol
Synonyms	(S)-1,2-Dichloropropane; (S)-(-)-1,2-Dichloropropane; L-1,2-Dichloropropane; (S)-Propylene dichloride; (-)-(S)-1,2-Dichloropropane; (S)-1,2-Dichloropropane enantiomer; (2S)-1,2-Dichloropropane; Chiral 1,2-Dichloropropane
EINECS	Contact for details

Quality Control

Our [S,(-)]-1,2-Dichloropropane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and impurity profile. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from strong acids and organic solvents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.