Description

L-Alanine (D7) is a stable isotope-labeled analog of the essential amino acid L-alanine, where seven hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry, NMR spectroscopy, and the development of labeled internal standards.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous alanine levels in complex biological matrices.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate amino acid metabolism, protein synthesis rates, and metabolic flux in cell cultures, tissues, and whole organisms.
• NMR Spectroscopy: Provides a non-radioactive tracer for structural and dynamic studies of proteins and peptides, leveraging the distinct magnetic properties of deuterium.
• Pharmaceutical Research & Development: Employed in the synthesis of deuterated drug candidates to study absorption, distribution, metabolism, and excretion (ADME) profiles and to potentially improve metabolic stability.
• Biochemical Assay Development: Acts as a key component in calibrating assays and developing diagnostic kits that require high-specificity detection of amino acids.
• Nutritional and Biomedical Research: Facilitates studies on muscle metabolism, liver function, and the role of alanine in gluconeogenesis under various physiological and pathological conditions.

Basic Information

Product Name	L-Alanine (D7)
CAS No.	74280-71-0
Molecular Formula	C₃H₂D₇NO₂
Molecular Weight	96.13 g/mol
Synonyms	(2S)-2-Aminopropanoic-2,3,3,3-d4 acid; L-Alanine-d7; (S)-Alanine-d7; Deuterated L-Alanine; Alanine (D7); L-2-Aminopropionic acid-d7; Alanine-2,3,3,3-d4; NSC 206315-d7
EINECS	Contact for details

Quality Control

Every batch of L-Alanine (D7) is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical assay, NMR and MS for isotopic enrichment verification, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA), which includes batch-specific data on purity, isotopic abundance, and physical properties, is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccants or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	+13.5° to +15.5° (c=1 in H₂O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.