Description

(R)-1,3-Dichlorobutane is a chiral organic compound belonging to the class of halogenated alkanes, serving as a valuable chiral building block and intermediate in advanced organic synthesis. Its defined stereochemistry at the chiral center makes it a critical precursor for the production of enantiomerically pure pharmaceuticals, agrochemicals, and specialty materials. This high-purity intermediate is essential for research and development laboratories, process chemists, and manufacturers in the fine chemical and life sciences industries seeking to introduce specific stereochemistry into complex molecular architectures.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material for the preparation of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in the development of cardiovascular and central nervous system (CNS) drugs.
• Agrochemical Precursor: Used in the synthesis of chiral herbicides, fungicides, and pesticides where specific stereochemistry is required for biological activity and environmental safety.
• Ligand and Catalyst Development: Serves as a building block for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of chiral polymers and liquid crystals with unique optical and electronic properties.
• Organic Chemistry Research: A versatile reagent for stereoselective alkylation and ring-closing reactions in academic and industrial R&D settings.
• Flavor and Fragrance Industry: Potential intermediate for the synthesis of chiral aroma chemicals and natural product analogs.

Basic Information

Product Name	(R)-1,3-Dichlorobutane
CAS No.	74259-52-2
Molecular Formula	C4H8Cl2
Molecular Weight	127.01 g/mol
Synonyms	(R)-1,3-Dichlorobutane; (R)-(+)-1,3-Dichlorobutane; (+)-(R)-1,3-Dichlorobutane; (R)-1,3-DCB; Butane, 1,3-dichloro-, (3R)-; (3R)-1,3-Dichlorobutane; (R)-sec-Butylene chlorohydrin dichloride; (R)-1-Chloro-3-chlorobutane
EINECS	Contact for details

Quality Control

Our (R)-1,3-Dichlorobutane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, GC for purity and impurity profiling, and identity confirmation via FT-IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability to maintain chiral integrity and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.1%
Residue on Evaporation	≤ 0.05%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.