Description

n-(4,5,6,7-Tetrahydro-1H-Indazol-5-Yl)Acetamide is a high-purity, advanced pharmaceutical intermediate with the CAS number 74197-10-7. This compound is a critical building block in modern medicinal chemistry, valued for its indazole-derived heterocyclic structure which is pivotal for developing bioactive molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

This specialized intermediate serves as a key precursor in several high-value chemical synthesis pathways. Its primary applications include:

• Pharmaceutical Intermediate: Core building block for the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Kinase Inhibitor Development: Used in research and production of protein kinase inhibitors, a major class of oncology and anti-inflammatory therapeutics.
• Chemical Biology Research: Serves as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-purity, complex heterocycles.
• Academic Research: Utilized in university and institutional labs for pioneering research in synthetic organic chemistry and drug discovery.

Basic Information

Product Name	n-(4,5,6,7-Tetrahydro-1H-Indazol-5-Yl)Acetamide
CAS No.	74197-10-7
Molecular Formula	C9H13N3O
Molecular Weight	179.22 g/mol
Synonyms	1H-Indazole-5-acetamide, 4,5,6,7-tetrahydro-; 5-Acetamido-4,5,6,7-tetrahydro-1H-indazole; N-(4,5,6,7-Tetrahydro-1H-indazol-5-yl)acetamide; Acetamide, N-(4,5,6,7-tetrahydro-1H-indazol-5-yl)-; 74197-10-7; Tetrahydroindazolylacetamide
EINECS	Contact for details

Quality Control

Our n-(4,5,6,7-Tetrahydro-1H-Indazol-5-Yl)Acetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.