Description

L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique fused bicyclic structure provides a rigid scaffold essential for constructing complex molecules with specific stereochemistry and biological activity. This compound is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), peptidomimetics, and specialized chemical intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of drug candidates targeting neurological and cardiovascular diseases.
• Peptidomimetics Research: Used to construct conformationally constrained peptide analogs to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Employed as a versatile building block for creating complex, enantiomerically pure molecules in medicinal chemistry.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and protein-protein interactions.
• Ligand Development: Serves as a core structure for developing novel ligands and catalysts in organometallic chemistry.

Basic Information

Product Name	L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	74163-81-8
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid; L-Tic; (3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid; L-Tetrahydroisoquinoline-3-carboxylic acid; (S)-Tic-OH; L-TIQ-3-COOH; (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and all materials are supported by comprehensive analytical documentation. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to meet rigorous pharmaceutical and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.