Description

(+/-)-Mephenytoin CAS NO 74007-05-9 is a chiral hydantoin derivative primarily recognized for its role as a reference standard and a key intermediate in pharmaceutical research and development. This compound is of significant interest in the study of stereoselective metabolism and the development of novel anticonvulsant agents. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require high-purity chemical building blocks for synthesis, analytical method development, and pharmacological studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control, method validation, and regulatory compliance in analytical laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral synthon in the research-scale synthesis of anticonvulsant and central nervous system (CNS) active compounds.
• Metabolic and Pharmacokinetic Studies: Employed in preclinical research to investigate stereoselective drug metabolism, enzyme activity (e.g., CYP2C19), and pharmacokinetic profiles.
• Academic and Industrial R&D: A valuable tool for medicinal chemists and biologists exploring structure-activity relationships (SAR) of hydantoin-based therapeutics.
• Impurity Standard: Used to identify and quantify related substances or degradation products in mephenytoin or analogous drug substances.

Basic Information

Product Name	(+/-)-Mephenytoin
CAS No.	74007-05-9
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	5-Ethyl-3-methyl-5-phenylhydantoin; Mephenytoin (racemic); Methoin; Mesantoin; Phenantoin; 3-Methyl-5-ethyl-5-phenylhydantoin; 5-Ethyl-5-phenyl-3-methyl-2,4-imidazolidinedione; (±)-Mephenytoin
EINECS	Contact for details

Quality Control

Our (+/-)-Mephenytoin is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing specific results for parameters such as assay, chiral purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.