Description

Methyl-D3 Triflate CAS NO 73900-07-9 is a deuterated isotopologue of methyl trifluoromethanesulfonate, serving as a critical reagent for introducing a labeled methyl group in organic synthesis. This compound is particularly valuable for its role in mechanistic studies, metabolic pathway tracing, and the synthesis of isotopically labeled compounds for analytical standards. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, site-specific deuterium labeling.

Application

• Deuterium Labeling in Pharmaceutical Intermediates: Used as a methyl-d3 donor in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) for drug metabolism and pharmacokinetics (DMPK) studies.
• Mechanistic Probe Synthesis: Employed in organic and organometallic chemistry to investigate reaction mechanisms by tracing the fate of the methyl group.
• Mass Spectrometry Internal Standards: A key precursor for creating stable isotope-labeled standards used in quantitative LC-MS and GC-MS analysis to ensure accuracy and precision.
• Agrochemical Research: Facilitates the development of labeled pesticide and herbicide analogs for environmental fate and residue analysis studies.
• Advanced Material Functionalization: Utilized in surface chemistry and polymer science to introduce labeled methyl groups onto substrates or polymers for specialized analytical characterization.
• NMR Spectroscopy: Serves as a useful reagent for preparing compounds with simplified NMR spectra, aiding in structural elucidation.

Basic Information

Product Name	Methyl-D3 Triflate
CAS No.	73900-07-9
Molecular Formula	C2D3F3O3S
Molecular Weight	164.12 g/mol
Synonyms	Trifluoromethanesulfonic Acid Methyl-d3 Ester; Methyl-d3 Trifluoromethanesulfonate; Deuterated Methyl Triflate; (2H3)Methyl Trifluoromethanesulfonate; Methyl-d3 Triflate; CD3OTf; Methyl-d3 Trifluoromethanesulphonate; Methyl-d3 Triflate-d0
EINECS	Contact for details

Quality Control

Our Methyl-D3 Triflate is manufactured under controlled conditions to ensure high isotopic and chemical purity, meeting the stringent requirements for research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D-atom %), chemical purity, and impurity profile. We adhere to rigorous internal quality standards to guarantee batch-to-batch consistency and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, it is recommended to handle and store the product under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Ideal storage temperature is between 2°C and 8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-atom %)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.