Description

3-Phenyl-3-(Trifluoromethyl)Diazirine is a specialized diazirine-based photoaffinity labeling reagent. This compound matters for its ability to generate highly reactive carbene intermediates upon photolysis, enabling the covalent cross-linking and study of biomolecular interactions. It is primarily needed by researchers and manufacturers in pharmaceutical development, chemical biology, and proteomics for mapping protein-ligand binding sites and other biological targets.

Application

• Photoaffinity Labeling (PAL): A critical tool in drug discovery for identifying and validating small molecule binding sites on proteins and other biological macromolecules.
• Chemical Biology Probes: Used to synthesize functionalized probes for studying enzyme mechanisms, protein-protein interactions, and metabolic pathways.
• Proteomics Research: Enables the covalent capture and isolation of target proteins for mass spectrometry analysis and structural elucidation.
• Material Science Cross-linking: Applied in surface modification and polymer chemistry to create covalently bonded networks under mild, light-initiated conditions.
• Bioconjugation: Facilitates the stable attachment of ligands, dyes, or other molecules to biomolecules for diagnostic and therapeutic applications.

Basic Information

Product Name	3-Phenyl-3-(Trifluoromethyl)Diazirine
CAS No.	73899-14-6
Molecular Formula	C9H5F3N2
Molecular Weight	198.15 g/mol
Synonyms	3-Phenyl-3-(trifluoromethyl)diaziridine; 3-Trifluoromethyl-3-phenyldiazirine; 3-(Trifluoromethyl)-3-phenyldiazirine; TPD; Phenyl(trifluoromethyl)diazirine; 3-Phenyl-3-(trifluoromethyl)diazacyclopropene; Diaziridine, 3-phenyl-3-(trifluoromethyl)-; Photoaffinity Labeling Reagent TPD
EINECS	Contact for details

Quality Control

Our 3-Phenyl-3-(Trifluoromethyl)Diazirine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to cGMP principles where applicable to support pre-clinical and development-phase requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between 2°C and 8°C (refrigerated) for long-term stability. The container should be kept in a well-ventilated area and protected from moisture. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.