Description

(5R,5Aα)-5,8,8Aβ,9-Tetrahydro-9β-(β-D-Glucopyranosyloxy)-5β-(3,5-Dimethoxy-4-Propoxyphenyl)Furo[3',4':6,7]Naphtho[2,3-D]-1,3-Dioxol-6(5Ah)-One is a complex, high-purity glycosylated naphthofuran derivative, valued for its unique molecular architecture and biological activity. This compound serves as a critical advanced pharmaceutical intermediate and a sophisticated research chemical for probing specific biochemical pathways. It is primarily required by pharmaceutical R&D and academic research institutions focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Biochemical Research: Used as a reference standard or probe compound in enzymatic studies and receptor binding assays to investigate specific biological mechanisms.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis projects and the study of glycoside chemistry.
• Process Development: Used in pilot-scale studies to develop and optimize scalable synthetic routes for complex molecules.

Basic Information

Item	Detail
Product Name	(5R,5Aα)-5,8,8Aβ,9-Tetrahydro-9β-(β-D-Glucopyranosyloxy)-5β-(3,5-Dimethoxy-4-Propoxyphenyl)Furo[3',4':6,7]Naphtho[2,3-D]-1,3-Dioxol-6(5Ah)-One
CAS No.	73839-72-2
Molecular Formula	C₃₀H₃₂O₁₃
Molecular Weight	600.57 g/mol
Synonyms	Podophyllotoxin 4-O-β-D-glucopyranoside derivative; 4-Desmethyl-4-propylpodophyllotoxin glucoside; 4-Propylpodophyllotoxin β-D-glucoside; NSC 348128; 9-(β-D-Glucopyranosyloxy)-5-(3,5-dimethoxy-4-propoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; (5R,5aR,8aR,9S)-9-(β-D-Glucopyranosyloxy)-5-(3,5-dimethoxy-4-propoxyphenyl)-5,5a,8,8a,9,10-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(11aH)-one
EINECS	Contact for details

Quality Control

Our (5R,5Aα)-5,8,8Aβ,9-Tetrahydro-9β-(β-D-Glucopyranosyloxy)-5β-(3,5-Dimethoxy-4-Propoxyphenyl)Furo[3',4':6,7]Naphtho[2,3-D]-1,3-Dioxol-6(5Ah)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets exacting research and development standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.