Description

5-Phenyl-5-Ethyl-D5-2-Thiobarbituric Acid CAS NO 73738-04-2 is a high-purity, deuterated analog of a key thiobarbituric acid derivative. This compound is essential for advanced analytical and research applications where isotopic labeling is required for precise tracking and quantification. It is primarily utilized by pharmaceutical research laboratories, analytical chemistry service providers, and manufacturers of reference standards engaged in method development and quality control.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical deuterated internal standard in LC-MS/MS and GC-MS analyses for accurate quantification of its non-deuterated counterpart or related metabolites in complex matrices.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies, metabolic pathway tracing, and bioanalytical method validation.
• Reference Standard Manufacturing: A key material for producing certified reference standards (CRS) and working standards for regulatory compliance and quality assurance testing.
• Metabolite Identification & Profiling: Aids in the identification and structural elucidation of drug metabolites in preclinical and clinical research.
• Chemical Synthesis Intermediate: Acts as a specialized building block for synthesizing novel deuterated compounds for research purposes.
• Forensic & Clinical Toxicology: Potential use in developing highly specific and sensitive assays for detecting barbiturate-class compounds.

Basic Information

Product Name	5-Phenyl-5-Ethyl-D5-2-Thiobarbituric Acid
CAS No.	73738-04-2
Molecular Formula	C13H10D5NO2S
Molecular Weight	254.36 g/mol (approx.)
Synonyms	5-Ethyl-5-phenyl-2-thiobarbituric acid-d5; 5-Ethyl-5-phenyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione-d5; 5-Phenyl-5-ethyl-2-thiobarbituric acid (deuterated); 5-Phenyl-5-ethylbarbituric-2-thione-d5; NSC 401443-d5; 2-Thio-5-ethyl-5-phenylbarbituric acid-d5; Deuterated Thiopental Related Compound; 5-Ethyl-5-phenyl-2-thiobarbituric acid (pentadeuterated)
EINECS	Contact for details

Quality Control

Our 5-Phenyl-5-Ethyl-D5-2-Thiobarbituric Acid is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), isotopic purity (D-content by NMR or MS), and identity confirmation. We adhere to cGMP principles for research materials, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.